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Legacy of Our Veterans' Military Exposures
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Protecting our veterans' children™

Gene-mutation find could help scientists combat diseases

Using genetic screening, a medical research team from National Taiwan University and collaborators from around the country said they have unearthed the mechanism of genetic mutation, a breakthrough that could prove useful in the quest to develop treatments for various forms of cancer and metabolic diseases.




“Biologists have found that there are dozens of acyltransferase and deacetylases [KDACs] in a human cell, maintaining the balance of acetylation and deacetylation,” Lin said, adding that acyltransferase and KDACs are like apps on a tablet PC, so when a certain acyltransferase joins with proteins in the cell, it performs certain functions, but KDACs are antagonistic toward the proteins and cause dysfunctions.


When an imbalance between the two occurs, such as when the body ages, KDACs tend to function more than acyltransferase and metabolic diseases are more likely to occur, Lin said.

Therefore, with the application of RNA interference (RNAi) technologies to analize the whole genome, the team was able to map out the interaction network of genes in histone deacetylase.



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