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Legacy of Our Veterans' Military Exposures
Justice - social, environmental, human
Protecting our veterans' children™

Research: Dioxin stimulates RANTES expression in an in-vitro model of endometriosis

The industrial contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with inflammatory disorders in women and other mammals.

In monkeys, exposure to dioxin correlates directly with an increased prevalence and severity of endometriosis (Rier et al., 1993; Yang et al., 2000).  However, the true effect of TCDD on human endometriosis remains a matter of debate (Kominckx et al., 1994; Mayani et al., 1997; Scialli, 2001).

Endometriosis is associated with abnormal immune responses in women affected by this disease (steel et al;, 1984; Braun and Dmowski, 1998).

These findings provide a mechanistic link between xenobiotic exposure, macrophage recruitment and inflammation in endometriosis.

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